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Image Search Results
Journal: The Journal of Biological Chemistry
Article Title: Transcription factor SOX15 regulates stem cell pluripotency and promotes neural fate during differentiation by activating the neurogenic gene Hes5
doi: 10.1016/j.jbc.2023.102996
Figure Lengend Snippet: Gene expression profile of Sox15 -knockout ESCs . A , RNA-seq analysis identifies differentially expressed genes (DEGs) in Sox15 KO1 ESCs compared to WT, plotted as a function of mean expression (fpkm) and fold changes (log2). Number of genes upregulated (830) and downregulated (589) are indicated. B , gene ontology (GO) analysis on DEGs in Sox15 KO1 ESCs compared with all annotated genes. p -value per GO classification is shown (-log10( p -value)). C , heatmap showing the relative expression levels of indicated genes from three biological replicates each of WT and Sox15 KO ESCs. Scaled values indicate relative downregulation ( red ) or upregulation ( green ) of gene expression. Genes from each category are manually curated. ESC, embryonic stem cell.
Article Snippet: RNA-seq samples were processed using the
Techniques: Expressing, Knock-Out, RNA Sequencing Assay